Eliezer Masliah Biography
Dr. Eliezer Masliah is a prominent neuroscientist known for his contributions to the study of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. He spent decades at the University of California, San Diego (UCSD), where his research focused on synaptic damage and its role in these diseases.
In 2016, he joined the National Institutes of Health (NIH) as the director of the Division of Neuroscience at the National Institute on Aging (NIA), overseeing significant research initiatives aimed at understanding brain aging and developing potential treatments for neurodegenerative disorders. His work led to the publication of hundreds of papers, many of which were influential in the early development of new therapies.
However, in September 2024, Masliah’s reputation was severely tarnished when an NIH investigation revealed that he had engaged in research misconduct. The investigation found that Masliah had falsified or fabricated images in at least two published studies, which involved reusing and mislabeling experimental results. The investigation, which covered more than 100 papers dating back to 1997, has raised doubts about the validity of much of his published work. As a result, Masliah has stepped down from his role at NIH, and actions are being taken to retract the affected studies.
Eliezer Masliah Age
Eliezer Masliah is 65 years old as of 2024.
Eliezer Masliah Nationality
Eliezer Masliah is of Israeli nationality.
Eliezer Masliah Educational Background
Eliezer Masliah completed his medical education at the National Autonomous University of Mexico (UNAM), where he earned his M.D. in 1982. He later pursued a residency in pathology at the National Institutes of Health in Mexico City, completing it in 1986. Following this, Masliah moved to the United States to further his training with a fellowship in neuropathology at the University of California, San Diego (UCSD), which he completed in 1989.
Eliezer Masliah Career
Eliezer Masliah is an internationally renowned neuroscientist with a long and impactful career focusing on neurodegenerative diseases, particularly Alzheimer’s and Parkinson’s. Over the course of his career, Masliah has made significant contributions to the understanding of the molecular mechanisms underlying these disorders. He is known for developing experimental models and novel therapies aimed at combating synaptic degeneration, and his research has positioned him as a leader in the field of neurodegeneration.
Early Research Contributions at UC San Diego
Masliah began his major career advancements at the University of California, San Diego (UCSD), where he held joint appointments as a professor in the Departments of Neurosciences and Pathology. During his tenure at UCSD, he also directed the Autopsy Service at the UCSD Medical Center, overseeing critical neuropathological studies. His early research focused on the molecular and cellular underpinnings of neurodegenerative diseases, which led to key breakthroughs, particularly in understanding how proteins like alpha-synuclein contribute to conditions like Parkinson’s disease and Alzheimer’s disease​.
Development of Novel Models and Therapies
One of Masliah’s key contributions while at UCSD was the development of transgenic pre-clinical models that mimicked Parkinson’s and Alzheimer’s diseases. These models allowed researchers to test new therapies targeting toxic proteins such as alpha-synuclein. His laboratory was instrumental in identifying gene therapy approaches, small molecule inhibitors, and immunotherapies aimed at halting or reversing neurodegeneration. Four of these therapeutic approaches advanced to phase II clinical trials, marking significant progress in the treatment of neurodegenerative diseases​.
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Leadership at the National Institute on Aging (NIA)
In 2016, Masliah transitioned from UCSD to the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), where he was appointed as the Director of the Division of Neuroscience. In this role, he has overseen NIH-funded programs dedicated to brain aging and neurodegenerative disorders, particularly Alzheimer’s disease and related dementias. His leadership at NIA has involved guiding research efforts aimed at reaching the U.S. national goal of finding effective treatments or preventive strategies for Alzheimer’s disease by 2025​.
Major Projects and Collaborative Efforts
During his time at NIA, Masliah has been pivotal in fostering international collaborations and expanding the scope of research on Alzheimer’s and Parkinson’s diseases. He has emphasized the importance of multi-country initiatives and large cohort studies, particularly in genetics and biomarkers, to advance the global understanding of these diseases. His efforts have also centered on harmonizing research approaches with similar international initiatives to pool resources and maximize impact​.
Research on Alpha-Synuclein and Proteinopathies
Masliah’s laboratory has played a crucial role in uncovering the significance of alpha-synuclein in various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Lewy body dementia. His research has shown how the buildup of toxic protein aggregates in the brain leads to synaptic dysfunction and, ultimately, cognitive decline. This work has been foundational in the development of therapeutic strategies aimed at reducing or preventing protein aggregation​.
Publications and Recognition
Masliah’s contributions to neuroscience are widely recognized, with over 900 research articles and numerous book chapters to his name. His prolific output and impactful research have earned him a reputation as one of the leading figures in the study of neurodegeneration. In addition to his scientific contributions, Masliah has held influential roles on various NIH advisory panels, contributing to the broader direction of neuroscience research across the country​.
Controversy and Research Misconduct
Despite his remarkable career, Masliah’s legacy has been clouded by allegations of research misconduct. In 2024, an NIH investigation found that he had falsified or manipulated images in several published studies, leading to the retraction of some of his work. This scandal has raised questions about the validity of certain aspects of his research, although his contributions to the field remain significant​.
Eliezer Masliah Wife and Children
There is limited publicly disclosed information regarding Eliezer Masliah’s family, including details about his wife and children.
Eliezer Masliah Net Worth
Eliezer Masliah’s net worth is not publicly disclosed.
FAQs
Who is Eliezer Masliah?
Eliezer Masliah is an internationally recognized neuroscientist who specializes in neurodegenerative diseases, particularly Alzheimer’s and Parkinson’s. He has been a prominent figure in advancing research on synaptic damage and protein misfolding diseases.
Where did Eliezer Masliah receive his education?
Masliah earned his medical degree from the National Autonomous University of Mexico (UNAM) in 1982 and completed his residency in pathology at the National Institutes of Health in Mexico City in 1986. He later did a fellowship in neuropathology at UC San Diego​.
What major positions has he held?
Masliah held joint professorships in the Departments of Neurosciences and Pathology at the University of California, San Diego (UCSD), and was also the Director of Autopsy Services at UCSD Medical Center. In 2016, he became the Director of the Division of Neuroscience at the National Institute on Aging (NIA).
What is his research focus?
Masliah’s research has primarily focused on neurodegenerative diseases, including Alzheimer’s and Parkinson’s. His work has been pivotal in understanding the role of proteins like alpha-synuclein in disease progression and developing novel therapies to target these pathways​.
How many publications does he have?
Masliah is a prolific author with around 900 research articles and multiple book chapters to his name. His work spans various aspects of neurodegeneration and experimental treatments​.
What contributions has he made to Alzheimer’s and Parkinson’s research?
Masliah was instrumental in developing transgenic models for Alzheimer’s and Parkinson’s diseases, as well as experimental therapies such as gene therapy, immunotherapies, and small molecule inhibitors that target protein aggregation​.
Has Eliezer Masliah been involved in any controversies?
In 2024, Masliah was embroiled in a scandal involving allegations of research misconduct, specifically related to image manipulation in over 130 of his papers. This has led to a reevaluation of some of his previously published work​.
